Your analysis gets to the very core of the patients experience: Its a matter of life and death, not just convenience
The pharmacokinetic rationale is questionable given the 5-day half-life, but some users report better side effect tolerance with split dosing
Reasonable approaches include: Regular blood work every 3-6 months checking metabolic markers, liver function, kidney function, and lipid profiles
These injections are often used as a part of a weight loss regimen, including a low-calorie diet
At that point, your provider can give you a better idea of the ideal therapy schedule for you
They are particularly beneficial for vegetarians and vegans (since B12 is found primarily in animal products), older adults with reduced absorption capacity, individuals with digestive conditions such as Crohn's disease or celiac disease, and anyone who has had gastric bypass surgery